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OVERVIEW
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Dualgen-10 has Minoxidil 10.0% with Azelaic Acid 5.0%. It achieves a good balance between hair regrowth and convenience. This product is also called DualGen-10 with PG because it has propylene glycol. The amount of minoxidil in this product is 2 times of that in Rogaine foam or Rogaine extra strength topical solution. In addition, a natural DHT blocker,Azelaic Acid , is added to this product.
EFFECTIVE INGREDIENTS-
Minoxidil: 10.0%
Azelaic acid: 5%
ABN complexTM: 0.8%
Retinol:0.025%
Caffeine: 0.001%
(If you need a higher strength of minoxidil, check out Dualgen-15 NO PG
INACTIVE INGREDIENTS-
Water, Propylene Glycol (low amount), Alcohol, Aloe gel
10% MINOXIDIL WORKS BETTER THAN 5% MINOXIDIL?-
Two large scale clinical studies compared the efficacy of 5% minoxidil and 2% minoxidil, one for male hair loss and the other for female hair loss. In both studies (~400 subjects), people were either given 5% minoxidil, 2% minoxidil, or placebo twice daily.
Results after 48 weeks (~1 year) showed 5% minoxidil offered much better results than 2%, and 2% minoxidil offered better results than placebo. “In men with AGA (androgenic alopecia or male/female pattern baldness), 5% topical minoxidil was clearly superior to 2% topical minoxidil and placebo in increasing hair regrowth, and the magnitude of its effect was marked (45% more hair regrowth than 2% topical minoxidil at week 48). Men who used 5% topical minoxidil also had an earlier response to treatment than those who used 2% topical minoxidil. Psychosocial perceptions of hair loss in men with AGA were also improved. ” Topical minoxidil (5% and 2%) was well tolerated by the men and women in the two clinical trials without evidence of systemic effects.
These trials clearly show hair regrowth is dosage dependent. The higher minoxidil strength is, the better hair regrowth is.
Will 10% minoxidil give twice as much regrowth as of 5% minoxidil? Most likely it won’t.
Will the higher concentration have higher side effects? Most side effects of minoxidil such as scalp itchiness or rashes are not caused by minoxidil itself, but by delivery vehicles such as alcohol or propylene glycol. These sides effects won’t be increased.
The minoxidil caused side effects may be increased but should be well tolerated because minoxidil has to have a serum concentration of 20 ng/mL to have any hemodynamic or other systemic effect in the human body. Large clinical studies involving thousands of patients showed a 2% minoxidil solution resulted in 0.6 ng/ mL and a 5% minoxidil solution resulted in 1.2 ng / mL of minoxidil in the serum. So, there is more than a 16-fold safety margin from the use of 5% topical minoxidil, and 8-fold safety margin with the use of a topical minoxidil 10 percent solution assuming the serum concentration is doubled when the topical minoxidil is increased from 5% to 10%. In reality, the serum concentration should be less double. Thus the safety margin is more than 8-fold.
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